RESEARCH

Anchor 6

Adolescence

and impulsive

choice

Substance use during adolescence has the potential to alter the developing prefrontal cortex and the behaviors that rely on mature prefrontal signaling. We study how alcohol, cannabinoid, and psychostimulant use during adolescence affects prefrontal activity and choices about probabilistic and delayed rewards in adulhood. Read more.

Inhibitory

control

Failures of inhibitory control play a role in a wide range of maladaptive behaviors, including obesity and substance use disorders. We study how prefrontal-striatal circuits respond to cues that trigger impulsive actions. Read more.

Modulation of reward processing

We compare sensitivities to different modalities of reward and examine how these sensitivities are modified by physiological and pharmacological signals. Read more.

Techniques

Cognitive behavioral tasks

Risk-preference

Reversal learning

Go/NoGo

Sustained attention

Delay discounting

Electrophysiology

Single unit recordings of prefrontal cortex and striatum

Pharmacology

Adolescent treatment with stimulants, cannabinoids

Voluntary consumption of alcohol

Brain stimulation reward

Chemogenetics

Excitatory and inhibitory DREADDS in prefrontal cortex

qPCR

Alterations in message for dopaminergic, cannabinoid, GABA-ergic and cholinergic receptors following adolescent substance use

Science through art

Baking Bad: Good gingerbread gone wrong

decision neuroscience

jamie donahey roitman

RESEARCH

Adolescence

and impulsive

choice

Inhibitory

control

Failures of inhibitory control play a role in a wide range of maladaptive behaviors, including obesity and substance use disorders. We study how prefrontal-striatal circuits respond to cues that trigger impulsive actions. Read more.

Modulation of reward processing

We compare sensitivities to different modalities of reward and examine how these sensitivities are modified by physiological and pharmacological signals. Read more.

Techniques

RESEARCH

Adolescence

and impulsive

choice

Inhibitory

control

Failures of inhibitory control play a role in a wide range of maladaptive behaviors, including obesity and substance use disorders. We study how prefrontal-striatal circuits respond to cues that trigger impulsive actions. Read more.

Modulation of reward processing

​We compare sensitivities to different modalities of reward and examine how these sensitivities are modified by physiological and pharmacological signals. Read more.

Techniques

We compare sensitivities to different modalities of reward and examine how these sensitivities are modified by physiological and pharmacological signals. Read more.